Vaccination against COVID starts at September 5 in Moscow

[goji]

So technically Russia never invaded Ukraine.

Technically, I would suggest Russia did invade the Crimea. However, as you say, the Crimea was traditionally part of Russia until Kruschev reassigned it to Ukraine, when Ukraine was still part of the USSR. That mistake was not corrected when the USSR broke up & the majority of the Crimean population want to be part of Russia.

I see Russia has some local elections now. I wonder if that's why Putin is so keen to make it look like Russia is leading the way with vaccine licensing ? When in reality he's just made it available before the phase 3 trial.

[Moses]

I see Russia has some local elections now. I wonder if that's why Putin is so keen to make it look like Russia is leading the way with vaccine licensing ? When in reality he's just made it available before the phase 3 trial.

No. For sure no. Here elections are going every year at the second Sunday of September. All: local (municipal), town/city (mayors and councils) , regional (oblast') and republican parliaments and governors (86 in total).

Putin himself does not support any of them (at least not does it openly). He is caring only about his approving rate, which is historically low, but still is above 50% (after Crimea it was >80%). He lost a lot because of unpopular pension reforms., but his rating is still above 50% because of peoples income: at time of Putin (at past 20 years) average personal income here grew over 4 time. Here is popular proverb, direct translation from Russian: "Refrigerators are still voting for Putin" (means full stocked with food refrigerators at homes, they were empty just 20 years ago, and people still remember it).

[goji]

his rating is still above 50% because of peoples income: at time of Putin (at past 20 years) average personal income here grew over 4 time. Here is popular proverb, direct translation from Russian: "Refrigerators are still voting for Putin" (means full stocked with food refrigerators at homes, they were empty just 20 years ago, and people still remember it).

After 70 years of communism and a few years of incompetence, any competent capitalist should have been capable of getting a large increase in wealth. Particularly when starting with a reasonably well educated population.

[Moses]

10 days of trial in Moscow. Vaccinated 31000 (rest have placebo). The only side effect - 14% had headache and temperature 37.5C at the next day after vaccination.

[StevieWonders]

10 days of trial in Moscow. Vaccinated 31000 (rest have placebo). The only side effect - 14% had headache and temperature 37.5C at the next day after vaccination.

A true “double blind” trial that lasted only 10 days? How many of those on the placebo reported side effects?

[Moses]

A true “double blind” trial that lasted only 10 days?

No. It is just 10 days. If you forgot: Sputnik V is 2-steps vaccine. After 10 days more they will have next injection. Then they will be under control for 3 or 6 month more.

[goji]

No. It is just 10 days. If you forgot: Sputnik V is 2-steps vaccine. After 10 days more they will have next injection. Then they will be under control for 3 or 6 month more.

This is simply in the early stages of the Phase 3 trial. Just like several other vaccines.
Except it's also for sale, despite the Phase 3 trial that is normally required to demonstrate safety not being completed. Mr Putin does things differently.

[Moses]

This is simply in the early stages of the Phase 3 trial. Just like several other vaccines.
Except it's also for sale, despite the Phase 3 trial that is normally required to demonstrate safety

No. Phase 3 is for to demonstrate effectiveness. Safety: phase 1 - animals and phase 2 - humans. What "safety" they can test for vector what is tested and used more than 6 years already in Russian vaccines against Ebola and SARS?

>>>>>>>Except it's also for sale

It isn't Putin's business. It is Moscow governor (mayor) Sobianin. As New-York city in US Moscow is "city-state" - governor here is quite independent from state and president. Moscow city's yearly budget is bigger than budget of Philippines or Qatar or Pakistan.

[goji]

What "safety" they can test for vector what is tested and used more than 6 years already in Russian vaccines against Ebola and SARS?

The vector is MODIFIED. So the modification could modify the results. Even if there is some hypothesis that suggests the modification is harmless, the hypothesis could be wrong.
So it's normal to prove it with a large trial to prove both the effectiveness AND the safety. Or that's how I interpret it from reading about various vaccines, including the Oxford one which is also a vector vaccine, using a modified adenovirus.

In most safety critical technical fields, unless there is 100% certainty in the theory, you test. I'm NOT claiming any medical expertise, but I do have experience of safety critical product development.

[Moses]

The vector is MODIFIED.

No. It is the same vector. Modification is in attachment: instead of small part of RNA Ebola or SARS viruses now small part of RNA of COVID-19 is attached. Such attachments are safe, any problem are limited to allergy only, because such small cuts from RNA are harmless. It is why vector method is going to be more and more popular in medicine.

Yes about Oxford. The difference of Sputnik V and Oxford is: Gamaleya already had ready modified and tested (5+ years for sure) adenovirus at time when they started to make vaccine, Oxford made vector "from the scratch" and have to prove its safety.

Gamaleya's problem now is to prove what they made correct cut from RNA and this part of RNA exists in all mutations of COVID-19, because vaccine will be effective only against mutations where such sample exists in RNA code. Also they need proof what in all cases level of antibodies generated by our immune system as a responce to vaccination will be high enough for to protect us from real virus, and also they need proof what such level will be high enough at least 1-2 years.