Quote Originally Posted by goji View Post
The vector is MODIFIED.
No. It is the same vector. Modification is in attachment: instead of small part of RNA Ebola or SARS viruses now small part of RNA of COVID-19 is attached. Such attachments are safe, any problem are limited to allergy only, because such small cuts from RNA are harmless. It is why vector method is going to be more and more popular in medicine.

Yes about Oxford. The difference of Sputnik V and Oxford is: Gamaleya already had ready modified and tested (5+ years for sure) adenovirus at time when they started to make vaccine, Oxford made vector "from the scratch" and have to prove its safety.

Gamaleya's problem now is to prove what they made correct cut from RNA and this part of RNA exists in all mutations of COVID-19, because vaccine will be effective only against mutations where such sample exists in RNA code. Also they need proof what in all cases level of antibodies generated by our immune system as a responce to vaccination will be high enough for to protect us from real virus, and also they need proof what such level will be high enough at least 1-2 years.